What sensitivity measures
Sensitivity — also called the true positive rate (TPR), recall, or the hit rate — is the proportion of people who genuinely have a condition that a test correctly identifies as positive. It answers a single question: of everyone who actually has the disease, how many does the test catch?
The formula is:
Sensitivity = TP / (TP + FN)
Here TP (true positives) is the number of diseased people who test positive, and FN (false negatives) is the number of diseased people the test wrongly clears. The denominator TP + FN is the total number of people who actually have the condition. Sensitivity is always a value between 0 and 1 (0% to 100%), and it depends only on the diseased group — it says nothing about people who are healthy.
Worked example
Suppose 100 people in a study truly have a disease. A screening test flags 90 of them as positive and misses 10. Then TP = 90, FN = 10, and sensitivity = 90 / (90 + 10) = 90 / 100 = 0.90, or 90%. The 10 missed cases are false negatives, giving a false negative rate of 1 − 0.90 = 10%.
Why sensitivity matters
A highly sensitive test is good at ruling a condition out: because it rarely misses true cases, a negative result is trustworthy. This is captured by the mnemonic SnNout — a highly Snsensitive test with a Nnegative result rules the disease out. Screening tests (for cancer, infectious disease, or newborn conditions) are deliberately built for high sensitivity, because the cost of missing a real case is severe.
Sensitivity versus specificity
Sensitivity has a mirror-image partner, specificity = TN / (TN + FP), the true negative rate. Sensitivity uses only sick people; specificity uses only healthy people. The two are usually in tension: lowering a test's positivity threshold catches more true cases (higher sensitivity) but also raises false alarms (lower specificity). A complete evaluation of a test reports both, often alongside predictive values, which — unlike sensitivity — also depend on how common the disease is (prevalence).
Typical reference values
- A rapid antigen test for a respiratory virus might have sensitivity around 70–85% (it misses some genuine infections).
- A well-run PCR or laboratory reference test often reaches 95–99% sensitivity.
- Mammography screening sensitivity is commonly cited near 85%, varying with breast density.
- Sensitivity of 100% means the test never misses a true case (FN = 0); sensitivity of 0% means it catches none.