About the GRACE score
The GRACE (Global Registry of Acute Coronary Events) risk score is a validated bedside tool for estimating in-hospital mortality in patients presenting with acute coronary syndrome — ST-elevation myocardial infarction, non-ST-elevation myocardial infarction, or unstable angina. Derived from the international GRACE registry and published in 2003, it remains one of the most widely used ACS risk models, recommended alongside clinical judgment in cardiology guidelines for early risk stratification.
How the score is built
The GRACE score sums points from eight variables measured at presentation:
- Age: points rise in bands from 0 for under 30 years to 100 for 90 years and older.
- Heart rate: points rise from 0 below 50 bpm to 46 at 200 bpm or above.
- Systolic blood pressure: points fall as pressure rises — 58 points below 80 mmHg down to 0 points at 200 mmHg or above.
- Serum creatinine: points rise from 1 below 0.40 mg/dL to 28 at 4.00 mg/dL or above.
- Killip class: a four-level measure of heart failure signs, worth 0 points for Class I (no failure) up to 59 points for Class IV (cardiogenic shock).
- Cardiac arrest at admission: adds 39 points if present.
- ST-segment deviation on the ECG: adds 28 points if present.
- Elevated cardiac biomarkers (such as troponin above the local upper limit): adds 14 points if present.
Adding the eight components gives a total that typically falls between about 1 and 372 points.
Interpreting the result
In the original derivation cohort, a total score of 108 or below is low risk, with roughly 1% in-hospital mortality; 109 to 140 is intermediate risk, with roughly 1-3% mortality; and above 140 is high risk, with mortality above 3%. Higher scores reflect more physiological derangement at presentation and, on average, worse in-hospital outcomes.
When to consult a professional
This tool performs the standard GRACE point arithmetic for education and reference. It is not a diagnosis and does not replace clinical judgment. Anyone with symptoms of a possible heart attack should seek emergency medical care immediately; risk-stratification decisions should always rest with the treating clinical team.